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Sr. Staff Scientist - Product Integrity Non Clinical Studies

Date: Mar 11, 2019

Location: Winston Salem, NC, US

Company: RAI

Reynolds American Incorporated is positively transforming the tobacco industry. We’re a family of companies that strives for success in everything we do. The future inspires us because our people are igniting the breakthroughs that are redefining the ways adult tobacco consumers enjoy tobacco in the 21st century.

When other companies talk about growth, they only talk about size. At RAI, we focus on the growth of our people. We take pride in each other’s growth and well-being throughout our careers. We invest in your career and total well-being because we know our companies succeed when our people thrive.

At the RAI companies you’ll have the opportunity to work on iconic brands and revolutionary products by collaborating with visionary, principled and passionate people every day.

This position is within Reynolds American Services Company—a subsidiary that provides support services, including compliance, HR, law, finance, information management, and more to all of the subsidiaries of RAI.

 

RAI Services Company (RAIS) is seeking a well-organized Senior Staff Scientist with in vitro toxicology expertise to support the assessment of tobacco products consistent with RAIS’ Growth, Innovation and Harm Reduction platforms. The Nonclinical Scientist (Senior Staff Scientist) is a member of a core group of scientists involved in developing and applying new in vitro approaches for the assessment of products. The individual will drive an innovative program and establish effective collaborations with a multidisciplinary team of internal and external groups to meet business requirements.

 

The incumbent will use in vitro models to assess changes in mammalian/human cells in response to tobacco or tobacco-related exposure. The incumbent will evaluate, develop and qualify/validate new alternative test methods, assays and in vitro models through engagement with stakeholders and relevant Contract Research Organizations (CROs)/external groups. The individual must independently manage and execute multiple projects, and maintain routine interaction with stakeholders to ensure critical timelines are met.

 

In this position, the individual must be a subject matter expert, will provide study oversight and train study monitors in application of various methods. The individual will disseminate results through internal meetings, external presentations and publications.

 

Principal Duties and Responsibilities:

 

  • Identify, develop, validate and apply alternative in vitro methods and models to support product assessment and regulatory submissions
  • Work closely with internal clients to implement research and testing strategies
  • Serve as Study Monitor and/or provide support as a scientific expert for model development and in vitro toxicology studies conducted through CROs and other institutions
  • Participate in the selection and qualification of applicable CROs
  • Manage the logistics of study initiation/conduct at CROs, including protocol development, budget management/tracking, ongoing oversight, troubleshooting, data interpretation/review and completion of final report
  • Conduct and/or oversee onsite monitoring visits and technical/compliance audits
  • Ensure GLP compliance in all applicable studies
  • Disseminate results through internal meetings, external presentations and publications.

 

 

POSITION QUALIFICATIONS

 

Required Education and Experience:

 

  • PhD in Toxicology, Cellular Biology, Biological Sciences, Biochemistry or closely related discipline
  • Minimum of 2-5 years of relevant experience conducting in vitro research and molecular toxicological studies

 

Required Skills

  • Experience in alternative in vitro model/assay development and method validation
  • Ability to conceive, plan and conduct strategic research objectives
  • Experience in oversight of in vitro toxicology studies
  • Knowledge of mechanisms of smoking/tobacco-related diseases 
  • Demonstrated ability to work both independently and as part of a team
  • Ability to apply critical thinking and problem solving skills
  • Demonstrated ability to manage and execute multiple projects simultaneously
  • Demonstrated project management, computer and data analysis  skills
  • Excellent interpersonal, written and oral communication skills
  • Ability to travel internationally

 

The ideal candidate will possess:

  • Experience with complex cell models including but not limited to organotypic and co-cultures,  and physiologically-relevant methods
  • Experience with molecular biology assays and bioinformatics tools
  • Knowledge of and experience with development and application of adverse outcome pathways (AOPs)
  • Experience with nonclinical studies using tobacco smoke and/or inhalation toxicology experience
  • Experience with in vivo studies and/or in vitro-in vivo connections
  • Established publication record in peer-reviewed journals; including primary authorship
  • Training and experience in the conduct of nonclinical studies compliant with 21 CFR part 58 and part 11 GLP regulatory requirements


Compensation/Targeted Bonus

  • Competitive Annual Salary
  • Targeted Annual Bonus
  • Relocation assistance available for those who qualify.

 

Benefit Summary

Our company offers very competitive compensation and benefit plans, including:

  • 401(k) plan that offers opportunity to save on pre- and post-tax basis up to 50 percent of eligible compensation. Company matches 100 percent of employee pre-tax/Roth (401k) contributions up to six percent
  • Comprehensive health- and welfare-benefits package
  • Eleven paid company holidays annually, plus a generous paid vacation plan based on length of service
  • Company-paid sick and personal days, funeral leave and jury duty leave
  • Confidential personal financial counseling service
  • On-site health clinics and fitness centers
  • A matching grants program that enables employees to direct and double their donations to qualifying charitable organizations of their choice
  • Health-care advocacy service
  • Volunteer service opportunities
  • Federal credit union membership through Allegacy Federal Credit Union
  • Extensive training opportunities  

 

ABOUT OUR ORGANIZATION:

Reynolds American Inc. is an indirect, wholly owned subsidiary of British American Tobacco p.l.c., and the U.S. parent company of R. J. Reynolds Tobacco Company; Santa Fe Natural Tobacco Company, Inc.; American Snuff Company, LLC; Niconovum USA, Inc.; Niconovum AB; R. J. Reynolds Vapor Company; Lorillard Licensing Company, LLC; and Reynolds Brands, Inc..


Reynolds American Inc. and its affiliated companies is an Equal Opportunity / Affirmative Action Employer.

All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.

Our organization offers a level of challenge, responsibility and creativity for motivated employees that stands apart from the crowd.

We are also committed to employing a diverse workforce and valuing different perspectives, experiences and talents to maximize the company's potential for successfully achieving its business objectives.

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Only applicants requiring reasonable accommodation for any part of the application and hiring process should contact us directly.

Email: TalentAcquisition@RJRT.com


Nearest Major Market: Winston-Salem

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